Naila Rahma Octaviya, Nita Pujiasih, Muhammad Dhiyaulkhaq, Willy Tirza Eden
Ketapang (Terminalia catappa) is among many traditional medicinal plants found in Southeast Asia, including Indonesia. Ketapang has been so common to be used as traditional medicine due to its various benefits, such as medicinal preparation for scabies and leprosy, as well as cure for stomachache and headache. According to previous research, Ketapang leaves extract showed antibacterial properties against Aeromonas salmonicida, Aeromonas hydrophila, Escherichia coli and Staphylococcus aureus. Thus, Ketapang leaves can be used as a remedy for skin diseases caused by bacteria, one of which is acne. Acne caused by excess oil gland activity, which is worsened by bacterial infection. This study aims to observe the effectiveness of gel preparation of chitosan loaded Ketapang leaves extract against acne-causing bacteria, Staphylococcus aureus and Escherichia coli. The effectiveness of gel preparation was measured based on a clear zone formed by the administration of antibacterial compounds diffused in the bacterial growth media. The result showed that the clear zone formed due to the growth inhibition of bacteria upon the application of nanogel preparation of Ketapang extract. The clear zone diameter was concentration dependent with the highest nanogel concentration of 5% to be the most effective against Staphylococcus aureus compared to conventional gel preparation of Ketapang extract. © 2025 Author(s).
Chemistry Department, Faculty of Mathematics and Natural Sciences, Universitas Negeri Semarang, Semarang, 50229, Indonesia; Pharmaceutical Science Department, Faculty of Medicine, Universitas Negeri Semarang, Semarang, 50229, Indonesia
