Widya Hary Cahyati, Nur Siyam, Efa Nugroho
Introduction: Semarang has been one of the endemic districts; since 2017, it has contributed to high dengue cases in Central Java. The study was conducted to see the mutation in the Voltage-Gated Sodium Channel (VGSC) Aedes aegypti genera. Materials and Methods: Aedes aegypti from 6 sub-districts in Semarang were examined, where each sub-district was taken from 2-3 villages endemic areas with high fogging intensity in Semarang. Ten larvae samples were taken from each village. Results and Discussion: The results showed that the resistant samples were 48.4% heterozygous and 51.6% homozygous resistant from Bawen, 100% heterozygous resistant from Bandungan, 73.3% heterozygous and 26.7% homozygous resistant from West Ungaran, 65% heterozygous and 35% homozygous resistant from Sumowono, 23.3% heterozygous and 66.7% homozygous resistant, and 10% still susceptible from Ambarawa, and 30% heterozygous and 70% homozygous resistant from East Ungaran districts. Conclusion: Based on the results of the molecular test, the Ae. Aegypti in Semarang Regency has proven resistance to the pyrethroid insecticide cypermethrin. © 2023 The Author(s). Published by Bentham Open.
Department of Public Health, Faculty of Medicine, Universitas Negeri Semarang, Semarang, Indonesia
