Ronny Lesmana, Farras Cahyo Bawono Setiawan, Siti Baitul Mukaromah, Hanna Goenawan, Vita Murniati Tarawan, Maya Kusumawati, Unang Supratman, Iwan Setiawan
Objective: Interleukin 12 (IL-12) has been of interest during the advancement of insulin obstruction in stout mice. Serum IL-12 levels have not precisely been decided in obese people and neither is its regulation by aquarobic training (recommended sport type for obese people which is less stressor for hefty individual joints). Aims: This research aims to discover the alteration pattern of IL-12 in serum of obese people based on BMI, examine their relationship with obesity-related parameters and how it can be modulated by aquarobic training. Methods: First study wasa cross-sectional study conducted on 34 obese adults ranging from 33 – 57 years old. The study used primary data which were blood samples from adult obese. For reducing the risk for the obese patients, in second study, we recruited 12 healthy volunteers for a 12 week aquarobic training program. Using enzyme-linked immunosorbent assay (ELISA) methods, we observed that serum IL-12 level was altered by different levels of BMI and correlated with other factors like Low Density Lipoprotein level, Cholesterol level and Waist Ratio. Results: The group with BMI between 27.01 – 29.99, have IL-12 level of 94.102 ± 35.19 pg/mL. Group with BMI 30.00 – 33.99 have 96.068 ± 59.44pg/mL, and those with BMI more than 33.99 have IL-12 level of 114.572 ± 74.22 pg/mL. Conclusion: Interestingly, it was observed that 12 week aquarobic training can significantly reduce the IL-12 level. Taken together, IL12 level may play an important role in obesity and can be potentially modulated by aquarobic training. © 2020 Lesmana et al.
Department of Anatomy, Physiology, and Biology of Cell, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Physiology Molecular Laboratory, Biological Activity Division, Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia; Laboratory of Sport Science, Sport Science Faculty, Universitas Negeri Semarang, Semarang, Indonesia; Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia
